Figure 5.
Figure 5. Comparison of TM1171 with E. coli transcription
regulator. (A) Ribbon diagram of E. coli transcription regulator
in complex with its DNA substrate (Parkinson et al. 1996). CRP
domain bound to DNA molecule A of the dimer is colored cyan and
the other is colored yellow. Regions defined by SEG to be
disordered are shaded red, while those for DXMS are shaded green
(Fig. 1 Go-). DNA is
represented by ball-and-stick. The figure was generated with
Bobscript (Kraulis 1991; Esnouf 1997) and Raster3d (Meritt and
Murphy 1994). (B) Superposition of TM1171 cNTP domain with its
counterpart in E. coli (PDB code 1RUN [PDB]
). TM1171 is colored red and 1RUN [PDB]
is colored yellow. The overall rmsd between the two domains is
1.74 Å over 111 aligned C residues; the
dimerization helix is rotated relative to its counterpart in
1RUN [PDB]
by about 20°.
The above figure is reprinted
by permission from the Protein Society:
Protein Sci
(2004,
13,
3187-3199)
copyright 2004.
). DNA is
represented by ball-and-stick. The figure was generated with
Bobscript (Kraulis 1991; Esnouf 1997) and Raster3d (Meritt and
Murphy 1994). (B) Superposition of TM1171 cNTP domain with its
counterpart in E. coli (PDB code 1RUN 
residues; the
dimerization helix is rotated relative to its counterpart in
1RUN