Figure 5.
FIG. 5. A model of rhodopsin-arrestin complex. Docking of
arrestin to rhodopsin with phosphorylated Rh-(330-348) region in
arrestin-bound state was manual, assuming interaction of the
phosphate groups with region 166-179 of arrestin, a site of
rhodopsin interactions with the most concentration of arginine
and lysine residues. -Strands containing the
region 166-179 and segments determining receptor specificity are
in purple. Inset highlights the interaction site. Phosphate
groups of rhodopsin are shown in red and labeled according to
the phosphorylated residue number. Lysine and arginine side
chains positioned for possible interactions with phosphates are
in blue and labeled.
The above figure is reprinted
by permission from the ASBMB:
J Biol Chem
(2004,
279,
51203-51207)
copyright 2004.
-Strands containing the
region 166-179 and segments determining receptor specificity are
in purple. Inset highlights the interaction site. Phosphate
groups of rhodopsin are shown in red and labeled according to
the phosphorylated residue number. Lysine and arginine side
chains positioned for possible interactions with phosphates are
in blue and labeled.