Figure 5 - full size

 

Figure 5.
Figure 5. Space-filling illustrations of the docking of (a) PA-14 and PA-14:1 and (b) PA-18 and PA-18:1 in the PLD active site. Hydrophobic (white), negatively-charged (red), and positively-charged (blue) surfaces. The positive surface at the center of the illustrations is composed of the putative catalytic residues His165 and His438, as well as Lys167 and Lys440. The hydrophobic cliff is at the bottom of the illustrations.

The above figure is reprinted by permission from John Wiley & Sons, Inc.: Proteins (2004, 57, 27-35) copyright 2004.