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Figure 5.
Figure 5. a, Stereo view of the superposition of
X(SSRI)bT.C1 (pink) and factor Xa (silver). For simplicity, the
inhibitor (1) is not shown. Note the re-registration of residues
Ser171-Ser178 and the formation of a hydrogen bond between
Ser178 O and Asn233 Nd2 in the case of X(SSRI)bT.C1. b, Stereo
diagram of the experimental electron density for X(SSRI)bT.B4;
residues 169-175 (green) are disordered, and only partial
density is present for Trp215 (violet). The ligand (4) is well
defined, binding as seen in Figure 2b. Density for the cystine
Cys168-Cys182 (orange) corresponds to the up conformation.
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