Figure 5 - full size

Figure 5. Figure 5. Recognition of the Nonhydrolyzable Substrate Analog, AMPCPR, and Three Mn2+ Ions by MT-ADPRase(A) Schematic representation. Residue 142 is from loop L9 that is not ordered without three manganese ions and AMPCPR.(B) Stereo diagram of the ADP-ribose binding site with AMPCPR and three manganese ions. Residues and substrate are shown using the same representation and color scheme of Figure 4A. Broken orange lines represent polar interactions among AMPCPR, three manganese ions, and protein residues.

The above figure is reprinted by permission from Cell Press: Structure (2003, 11, 1015-1023) copyright 2003.