Figure 5.
Figure 5 Structural comparisons of the DI -mAChE complex with
the Fas2 -mAChE complex and the crystalline mAChE tetramer. (A)
Close-up view of a superimposition of the DI molecule (orange
bonds, blue nitrogen and red oxygen atoms) in the DI -mAChE
complex with the interacting central loop (loop II) of Fas2
(yellow) bound to mAChE in the Fas2 -mAChE complex (1KU6),
according to all C[ ]atoms
of mAChE in the two structures. The Fas2 side chains that match
the structural determinants of the DI molecule are displayed as
green bonds. (B) Superimposition of the DI molecule (colored as
in A) in the DI -mAChE complex with the PAS-occluding short loop
(yellow) of subunit A in the mAChE tetrameric assembly (1MAA),
according to all C[ ]atoms
of mAChE in the DI -mAChE complex and in the tetramer subunit C.
Those of the mAChE short loop
side chains that match the structural determinants of the DI
molecule are displayed as orange bonds. The mAChE molecular
surfaces buried at the Fas2 -mAChE complex interface (A) and at
the loop
-PAS interface (B) are shown in transparency.
The above figure is reprinted
from an Open Access publication published by Macmillan Publishers Ltd:
EMBO J
(2003,
22,
1-0)
copyright 2003.
]atoms
of mAChE in the two structures. The Fas2 side chains that match
the structural determinants of the DI molecule are displayed as
green bonds. (B) Superimposition of the DI molecule (colored as
in A) in the DI -mAChE complex with the PAS-occluding short 
loop
(yellow) of subunit A in the mAChE tetrameric assembly (1MAA),
according to all C[