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Figure 5.
Fig. 5. Electrostatic potential surface showing the
TRTK-12-binding site on Ca^2+-S100B. Negative potential is
indicated in blue, and positive potential is shown in red for
Ca^2+-S100B. A, location of the two TRTK-12 molecules ( green)
on opposite sides of Ca^2+-S100B. The TRTK-12 peptide fits into
the hydrophobic cleft generated by helices III and IV of each
monomer. Note that on either side of the TRTK-12-binding site a
significant uncharged region exists. B, environment of the
anchoring Trp7 residue from TRTK-12 (green) showing interactions
with S100B residues (blue) in helix III (Val56 and Thr59) and IV
(Phe^76 and Val80).
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