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Figure 5.
Figure 5. View of the extracellu-
lar side, showing an extensive
hydrogen-bonding network of side-
chains and water molecules, as
well as the alternate conformation
of Glu194. Not only is the hydro-
gen-bonding network between the
Schiff base and the proton release
group broken, but Arg82 is now in
a downward configuration with
hydrogen bonds towards the pro-
ton release group similar to what is
observed for M intermediates.
Somewhat long hydrogen bonds
exist from Arg82-NH2 to water 408
(3.44 Å ) and from Arg82-NH1 to
water 409 (3.25 Å ).
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