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Figure 5.
Figure 5. Stereo Picture of the Main Intermolecular
Interaction in the Tetragonal Form of Cyp40 and an Overlay of
the Folding Intermediate Dimer and the Fully Folded Conformer(a)
The partially unfolded TPR domains form a symmetrical dimer. One
molecule is colored as in Figure 3b, and the partner molecule is
colored red. The first TPR, comprising helices P and Q (shown in
the boxed region), make an intermolecular contact with helix R'
of the dimer-related molecule.(b) The boxed region of (b), with
the same color scheme, showing helices P, Q, and R' for the
tetragonal form, overlaid with helices P, Q, and R (yellow) of
the folded TPR domain of the monoclinic form. The intra- and
intermolecular interactions of helix R with helices P and Q are
seen to be nearly identical
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