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Figure 5.
Figure 5. (a) A stereo view of N-MeMP bound to
ferrochelatase. The side-chains of amino acid residues in close
contact with the inhibitor are also shown. WAT represents a
solvent molecule coordinated to H183 and E264. This molecule may
easily be replaced by a metal ion at the first stage of the
enzymatic reaction. (b) A surface representation of the binding
pocket for N-MeMP. The red and blue colors correspond to
negative and positive surface potential, respectively. The
position of the tilted pyrrole ring A shows that any changes in
its conformation will result in steric clashes with protein
side-chains. The Figure was produced with the program GRASP
(Nicholls et al., 1991).
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