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Figure 5.
Figure 5. Superposition of antistasin-type inhibitors.
(a) Stereo superposition of bdellastasin (blue), tissue-kal-
likrein-bound hirustasin (green), and the N-terminal
(red) and the C-terminal (magenta) domain of antistasin.
The superposition is based on the C
a
atoms of residues
24-52 of hirustasin and residues 28-55 and 83-110 of the
N and C-terminal domains of antistasin, respectively.
The N and C-terminal subdomains are indicated.
(b) Stereo superposition of the N-terminal subdomains
of bdellastasin (blue), tissue-kallikrein-bound hirustasin
(green), and subdomains Nn (red) and Cn (magenta) of
antistasin. The N and C termini are marked and the
residues Glu15 and Glu69 of the interface contact loops
of N and C-terminal subdomains of antistasin are high-
lighted. Yellow connections indicate disulphide bridges.
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