Figure 5 - full size

Figure 5. Figure 5. eIF4GII and 4E-BP1 Peptides Binding to the Convex Dorsal Surface of eIF4EGRASP ([8]) representation of the eIF4E surface, colored coded for electrostatic potential (red < −10 kBT; blue > 10 kBT), calculated in the absence of the peptides (see Figure 5C in [21]) using a water probe radius of 1.4 Å. The (A) eIF4GII and (B) 4E-BP1 peptides are depicted with orange and yellow, respectively. (C) Overlay of the eIF4GII (orange) and 4E-BP1 (yellow) peptides with the solvent-accessible convex surface of eIF4E, colored green for residues that are absolutely conserved among all known eIF4E sequences ([21]).

The above figure is reprinted by permission from Cell Press: Mol Cell (1999, 3, 707-716) copyright 1999.