Figure 5 - full size

 

Figure 5.
Fig. 5. Stereo view of a superimposition of the chloroquine complex onto the coordinates of ternary pfLDH (PDB code 1ldg.pdb, Ref. 1) showing that the quinoline ring occupies a position similar to that of the adenyl ring of NADH. Protein residues within 3.5 Å of the NADH from the ternary complex are shown in green and those within 4.5 Å of chloroquine from the CQ-pfLDH complex are shown in red. The chlorine atom of chloroquine is depicted as a red sphere.

The above figure is reprinted by permission from the ASBMB: J Biol Chem (1999, 274, 10213-10218) copyright 1999.