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Figure 5.
Figure 5. Structure of the HPPK monomer. (a) In the overall
view β-strands are presented as arrows and α-helices are shown
as ribbons. The inhibitor in the active site is represented by
the ball-and-stick model in green. (b) The molecular surface of
the enzyme in the absence of compound [II] depicts the position
of the conserved charged amino acid residues in the proximity of
the pterin binding site. The surface is colored red and blue for
negative and positive char respectively. The Figure was produced
using the programs MOLSCRIPT [Kraulis 1991] and RASTER3D [Merrit
and Bacon 1997]. The surface was generated and displayed with
the program GRASP [Nicholls and Honig 1992].
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