Figure 5.
Figure 5. A Comparison of the FKBP12–FK506 and FKBP12–T
β R-I ComplexesA surface representation of FKBP12 bound to
FK506 is shown to the left ([57]). To the right is shown a
surface representation of FKBP12 bound to the T β R-I GS
region. Leu-195 and Leu-196 are bound in the same hydrophobic
pocket used to engage immunosuppressant.
The above figure is reprinted
by permission from Cell Press:
Cell
(1999,
96,
425-436)
copyright 1999.
