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Figure 4.
Figure 4 Surface representations of SH3 domains from Abl, Sem5
and Amph2. The pictures on the left depict surface accessible
hydrophobic regions coloured green to yellow for increasing
hydrophobicity (M.Noble, X objects, unpublished). Amph2 SH3
shows only two hydrophobic patches as opposed to the three
present in Abl and Sem5. On the right are representations of
electrostatic potential (created using GRASP) showing the large
negatively charged patch (red) on the peptide binding surface
(the peptide is shown in the case of Abl and Sem5). The
representations show the peptide binding surfaces of the SH3
domains with the n-Src loops pointing toward the top of the
page. Coordinates for the SH3 domain of Abl (Musacchio et al.,
1994) and the N-terminal SH3 domain of sem5 (Lim et al., 1994)
were obtained from the Protein Data Bank.
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