Figure 4 - full size

Figure 4. Fig. 4. Schematic summaryofbinding interactions for HONH-iBM-L-Asp-NHBn,and HONH-~BM-L-A~~-NHBN(~-NH~). CH-0 type are listedinparentheses.lthough the ovrallsetof interactions emain similar, specific interactions change with the eta-aino group of HONH-iBM-L-Asn-NHBn(m-NH2) (hydrogen bond to Leu193CO).theAsp-Asnrepacement (likely interposi- ionofawater molecule), anda shift n the inhibitor position (weaker interactions toawater molecule).

The above figure is reprinted from an Open Access publication published by the Protein Society: Protein Sci (1998, 7, 1303-1309) copyright 1998.