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Figure 4.
Figure 4. (a) Stereoview of dicoumarol bound to FRase I,
highlighting the trans-conformation of dicoumarol such that the
corresponding keto-oxygens of the two coumarols point in
opposite directions. Residues within 4 Å from the buried
half of dicoumarol are also shown and labeled, highlighting
hydrophobic interaction with the inhibitor and protein. (b) A
chemical structure of dicoumarol.
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