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Figure 4.
Figure 4. Stereo view of the contacts made by finger one in
the complex between (a) the RADR peptide and the targeted GCAC
binding site, (b) the RADR peptide and the wild-type GCGT
binding site, (c) the RADR peptide and the GACC binding site,
and (d) the wild-type Zif268 peptide and the GCAC binding site.
The sidechains of residues 18, 20, 21 and 24 (positions -1, 2, 3
and 6 of the a helix) and the peptide backbone are shown in gold
for the RADR peptide, with alternate conformations indicated in
gray. The wild-type peptide is shown in magenta, with alternate
conformations indicated in gray. Water molecules are represented
as spheres; only those water molecules that mediate interactions
between the peptide and base pairs 8-10 are shown. The DNA is
color-coded by strand, with the primary strand in purple and the
secondary strand in blue. Fingers two and three are not shown.
(The figure was made with the program SETOR [30].)
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