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Figure 4.
Fig. 4. Van der Waals interaction of Phe^A53, Val^A48 and
the P[3] subsite of saquinavir in the structural model of HIV-1
mutant protease G48V complex with saquinavir. The saquinavir
positions in the wild-type crystal structure (orange) and of the
G48V mutant model structure (yellow) are both shown. There is
a 30° rotation of the saquinavir P[3] planar quinoline group
(double ring) in the G48V complex compared to that in the
wild-type enzyme. This change appears to be a result of its
interaction with Val^48. The van der Waals interaction between
Val^48 and Phe^53 is shown but the view does not minimize
overlap of the surfaces.
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