Figure 5 - full size

Figure 5. Fig. 5. Diagramofesentialresiduesthatcontribtetonucleotidebindingndcatalysis. A: Inhibitorternarycomplex. Dis- tancesaretakenfromtheternarycomplexof C:IPZO:ATP (Zhengetal.,1993~).Thecrystalsweresoaked in MnZ*, andboth theinhibitorandtheactivatingmetalsareshown (++) (Zhengetal., 1993~).The activating metal bridges the p- andy-phosphates, whereastheinhibitorymetalbridgesthe Y- andy-phospates.Thearrowbridgesthemethylsidechain f theP-siteAlaand they-phosphate of ATP. B: Substrateternarycomplex. C: Phosphorylatedsubstratebinarycomplex.

The above figure is reprinted from an Open Access publication published by the Protein Society: Protein Sci (1994, 3, 176-187) copyright 1994.