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Figure 4.
Figure 4. Structural Comparisons of the Catalytic Domain of
AvPCP
(A) Structural superimposition of the catalytic
domains of AvPCP (green) and papain (PDB ID code 9pap; orange)
in stereo. The catalytic triad of each protein is shown as
sticks.
(B) Comparison of AvPCP with representative
papain-like proteins: papain, Spr, the CHAP domain of GspS
(Gsps-N), 2p1g (PDB ID code 2p1g), and NsPCS (PDB ID code 2bu3).
The structures are shown in the same orientation of their
catalytic domains.
(C) Four representative active-site
pockets. The cysteine in the catalytic triad is colored in red,
the histidine in blue, and the third polar residue in cyan (seen
only in 2p1g, buried in others). The S sites (labeled S) are
tentatively assigned based on papain.
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