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Figure 4.
Surface features of sclerostin. Panels A and B show contact
surface views of sclerostin, which are colored according to
electrostatic potential, with areas of significant positive
charge shown in blue, significant negative charge in red, and
neutral in white. The orientation of the protein in panel A is
equivalent to the ribbon representation in panel C. The location
of the hydrophobic patch on the concave surface of the extended
finger-like structures is indicated by the arrow. Panels C and D
show a ribbon representation of sclerostin, with the positions
of the basic side chains from arginine and lysine residues
highlighted.
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