Figure 4.
Fig. 4. A second Trp molecule is bound between R30 and D404 of
the extracellular gate only in the open-to-out conformation. (A)
Trp602 bound in the extracellular vestibule of LeuT, residing
between D404 and R30, flanked by the -helix in TM10. (B)
Extracellular vestibule of the LeuT-SeMet complex.
Anomalous-difference Fourier map (contoured at 5 and 15 and depicted in
green and blue mesh, respectively) showing no substantial
density peaks in the extracellular vestibule.
The above figure is reprinted
by permission from the AAAs:
Science
(2008,
322,
1655-1661)
copyright 2008.
-helix in TM10. (B)
Extracellular vestibule of the LeuT-SeMet complex.
Anomalous-difference Fourier map (contoured at 5 
and 15