|
Figure 4.
Fig. 4. Can2 complex with the product analog acetate. (a)
Overall structure of the Can2/acetate complex (monomer C, gray)
overlaid with the structure of uncomplexed Can2 (blue). The
Zn^2+ ions are shown as orange spheres. (b) Overlay of the
active sites of the Can2/acetate complex and the Can2 structure
with a bound water molecule (blue: Can2/water structure;
aquamarine: Can2/acetate monomer A; cyan: Can2/acetate monomer
B; gray: Can2/acetate monomer C). (c) Modeling of a
Can2/benzolamide complex. Residues coordinating the active-site
ion, restricting the space available to the inhibitor, or
reachable for the inhibitor moieties are labeled.
|
