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Figure 4.
Fig. 4. Superposition of the gp41 peptide epitope
conformations found in eight different crystal structures.
Superposition was performed using Cα atoms of the entire
F[ab]′ fragment, in addition to the epitope peptide. gp41
peptide residues are shown as stick models: PDB ID 2P8L (green),
PDB ID 3D0V (cyan), PDB ID 2P8P (magenta), PDB ID 1TJH (yellow),
PDB ID 2P8M (salmon), PDB ID 3DRO (light gray), PDB ID 3D0L
(blue), and PDB ID 3DRQ (orange). The conformation of residues
^651LELDKWAS^668 when bound to 2F5 F[ab]′ is conserved in all
structures, whereas the conformation of residues ^669LW^670
varies significantly in structures 2P8P, 1TJH, and 3D0L. The
RMSDs for all atoms of these peptides are given in Table 2.
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