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Figure 4.
Analysis of the citrate-binding pocket. Stereoscopic figure
of residues contributing to the citrate-binding pocket in (A)
crystal form A, (B) crystal form B, and (C) the citrate complex.
In all three, the protein is shown as sticks colored by atom
type (carbon: green, oxygen: red, nitrogen: blue, sulfur:
yellow), with water molecules shown as red spheres. In crystal
form B, the chloride ion is shown as an orange sphere (B) while
in the citrate complex (B) the citrate is shown as sticks
colored by atom type, except that the carbon atoms are in cyan.
Comparison of the three sites shows that minimal rearrangement
of the site has occurred to adapt to citrate binding.
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