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Figure 4.
Linezolid overlaps A-site ligands at the peptidyltransferase
center. (A–F) Comparison of the binding site of linezolid
(pink) on D50S (A) with chloramphenicol (PDB ID code 1K01;
green) (6) (B), anisomycin (PDB ID code 1K73; olive) (3) (C),
tiamulin (PDB ID code 1XBP; teal) (7) (D), clindamycin (PDB ID
code 1JZX; magenta) (6) (E), and A- (yellow) and P-site (orange)
phenylalanyl-tRNA CCA-end mimics (PDB ID code 1VQN) (27) (F). In
all cases, U2585 (blue) from the D50S-linezolid structure is
shown for reference.
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