|
Figure 4.
Fig. 4. A representative structure of HIV-2 myr(+)MA (slate)
and comparison with the HIV-1 myr(+)MA protein (sand). (a)
Semitransparent surface representation of MA showing the
penetration of the myr group (red sticks) and interactions with
the side chains of Val7, Leu8, Leu16, Ile34, and ILe85 (green
sticks). (b) Cartoon representation of the HIV-2 and HIV-1
myr(+)MA proteins comparing the sequestration of the myristate
group (red) in the hydrophobic cavity formed by residues Val7,
Leu8, Leu16, Ile34, and Ile85 (green spheres). (c)
Superimposition of representative structures of HIV-2 and HIV-1
myr(+)MA. Myristate groups of HIV-2 and HIV-1 myr(+)MA proteins
are packing against Leu16 and Trp16, respectively. NMR data
revealed that helix 6 is flexible for both proteins. (d) An
expanded view of the protein core of HIV-2 and HIV-1 myr(+)MA
showing the myristate packing against side chains of Leu16 and
Trp16, respectively.
|
