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Figure 4.
Hydroxamate inhibitor binding of cdHDAC7. A and B, the 2|F[0]
- F[c]| electron density maps for the bound zinc and inhibitor
molecules in the active site of cdHDAC7 are contoured at 0.9σ
(blue). TSA (A) and SAHA (B) are shown as stick models colored
as per atom type: carbon in green, oxygen in red, and nitrogen
in blue. C, the TSA molecule bound in the cdHDAC7 active site is
shown as a sphere model. The histidine residue His-843 points
away from the active site, resulting in an enlarged active site
pocket.
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