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Figure 4.
Figure 4 (a) 2piz (8300 nM) bound to pp-CpB. (b) 2pj0 (160 nM) bound
to pp-CpB. The green lines show the network of hydrogen bonds
formed by the carbamate group. These hydrogen bonds are also
formed by the inhibitors when the carbamate is replaced by
either an amide or a sulfonamide group. (c) Alternate S1
substituents: 2pj0, green (160 nM); 2pj4, ivory (190 nM); 2pj5, cyan (930
nM). (d) Alternate S2 substituents: 2piy, green (2 nM); 2pj6,
ivory (7 nM); 2pj8, cyan (4 nM); 2pj9, dusty rose (5 nM).
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