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Figure 4.
Hydrogen bond network between the CERT START domain and
C[16]-ceramide (A). Large white letters, amino acid residues
interacting with the ceramide; small white letters, α-helix and
β-sheet strands, numbered; green meshes, ceramide omit map
contoured at 2.5 σ; orange dashed lines, hydrogen bonds; red
circles, water molecules. In the wire model, N and O atoms are
highlighted by blue and red, respectively. The ceramide molecule
(yellow) and the side chains of the CERT START domain are shown
by wire models. (B) Water-mediated stabilization of O1 oxygen of
ceramide viewed in the direction opposite to A.
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