Figure 4 - full size

Figure 4. Figure 4. Substrate Binding to OMPD (A and B) Stereo representation of the Asp312Asn OMPD-OMP complex showing a bent carboxylate group. (C and D) Stereo representation of the Asp312Asn 6-HMUMP-OMPD complex. The hydroxymethyl group is also bent out of plane, indicating that electrostatic repulsion by Asp317b is not responsible for substrate deformation.

The above figure is reprinted by permission from Cell Press: Structure (2008, 16, 82-92) copyright 2008.