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Figure 4.
Figure 4. Structures of BoNT/A-LC(1–424) Bound to
Hydroxamate Inhibitors
Stereo representations of the three
enzyme-inhibitor complexes ([A], LC:1; [B], LC:2; [C], LC:3)
showing the unweighted 2|F[o]| − |F[c]| simulated annealing
composite omit electron-density maps (green mesh) for the
inhibitor and residues 366–372 (the 370 loop) contoured at
1.25σ. Active-site residues are represented as cylinders with
gray carbon atoms. The inhibitors are shown in ball-and-stick
representation with brass carbons. The catalytic Zn(II) ions are
rendered as metallic spheres. This figure was rendered using
POVScript+ [48] and [49] and POVRAY (www.povray.org).
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