Figure 4 - full size

Figure 4. Figure 4. Guanine-specific interactions between the initiating GTP nucleotides and the active site residues of the polymerase. (a) Interaction of the first G:C base-pair between GTP (gold) and the + 1 cytosine on the template (blue) with RNAP. (b) Interaction of the second G:C base-pair between GTP (gold) and the + 2 cytosine (blue) on the template with the RNAP.

The above figure is reprinted by permission from Elsevier: J Mol Biol (2007, 370, 256-268) copyright 2007.