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Figure 4.
Figure 4. PEP binding to PFKFB3. (a) The |F[o]|–|F[c]| omit
electron density map. The map is calculated in the absence of
ligands and contoured at 2.5σ. (b) A stereo view of the
interactions of PEP with the 2-Kase active site pocket is shown.
The dotted lines represent hydrogen bonds or salt-bridges. To
show its position in the 2-Kase active pocket, the structure of
PFKFB3 radical dot AMPPCP radical dot Fru-6-P complex is
superposed and Fru-6-P (light gray) is shown.
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