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Figure 4.
Fig. 4. TRAP-tail binding interferes with substrate
binding. Shown is a stereoview of the PfAldo:TRAP-tail complex
superimposed onto the structure of human aldolase A complexed
with F1,6P (30) (PDB ID code 4ALD). Key residues enabling the
accommodation of the penultimate Trp-indole ring are highlighted
as sticks. The TRAP-tail is shown in magenta, residues involved
in substrate binding in blue, and human aldolase A in yellow.
The substrate F1,6P are shown as sticks in green, with the two
phosphate groups in orange. The C-terminal TRAP-tail residue
partially occludes the substrate-binding site.
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