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Figure 4.
Fig. 4. LpxD–FA complex. (A) Identification of bound FA.
GC-MS analysis, chain length, and saturation states are
indicated, and the key shows the relative percentages. (B)
Surface view of conserved residues with ligands depicted as
sticks. Palmitic acid is colored cyan, and UDP-GlcNAc is colored
according to atom type: C, white; N, blue; O, red. Conserved
residues are colored by type; basic residues are blue with the
exception of His-247 and His-284, which are colored green.
Acidic residues are red, aromatic residues are salmon, glycine
residues are yellow, polar residues (Asn, Gln, Ser, Thr, and
Cys) are slate blue, and aliphatic residues (Ala, Ile, Val, Leu,
Met, and Pro) are magenta. Colored residues that form part of
the FA and UDP-GlcNAc binding pockets include Gly-262, Gly-280,
Gly-265, Ala-246, Ile-263, Ala-264, Asp-240, and Gln-244.
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