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Figure 4.
Fig. 4. The ligand-binding pocket. (A) Conserved amino acid
residues involved in ligand binding. Red, green, and blue stick
models represent the structures for mGluR-I[1], mGluR-II[3], and
mGluR-III[7], respectively. The three closed protomers were
superimposed by least-square fitting. The model of the closed
mGluR-III[7] was constructed as described in the text. (B)
Difference in the open angle of the closed protomer between
mGluR-I[1] (purple) and mGluR-II[3] (green). The yellow stick
model represents the bound Glu. The black arrow indicates the
view direction in A. (C–E) The ligand-binding pockets of
mGluR-I[1] (C), mGluR-II[3] (D), and mGluR-III[7] (E) as viewed
in A. Each molecular model is colored as in Fig. 1B. Red lines
indicate the conserved surface shown in A. (F) Diagram
representing the DCG-IV binding of mGluR-II[3], viewed from
directions similar to that in A. The structure of the closed
protomers of mGluR-I[1] (green) (4) is superimposed onto the
mGluR-II[3]structures (yellow).
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