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Figure 4.
Figure 4. The Overall Structure of yHst2 I117F Bound to
Carba-NAD^+ and Acetyl-Lysine
(A) Simulated annealing omit
density contoured at 1.0 σ showing density for the protein
(gray), carba-NAD^+ (cyan), acetyl-lysine (magenta), and the
mutated I117F residue (yellow).
(B) The superposition of
the nicotinamide-bound yHst2/ADP-HPD/H4 and the yHst2
I117F/carba-NAD^+/H4 structures. The yHst2 protein is shown in
blue, and the mutated I117F side chain (yellow) and the
nicotinamide molecule (red) are shown both in stick and modeled
in terms of the van der Waals radius of each atom of the
molecules.
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