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Figure 4.
(a) The ELS4 TCR crumples the EPLP peptide. Non-ligand-bound
(yellow) and ligand-bound (orange) conformation of the EPLP
peptide. ELS4 V  domain,
magenta; ELS4 V[  ]domain,
cyan. 1
and 2
helices of ligand-bound HLA-B^*3501, gray ribbon. For clarity,
the peptide is presented without the backbone details and
includes only the side chains. (b,c) Peptide conformational
changes with distinct views. Non-ligand-bound (yellow with black
labels) and ligand-bound (orange with red labels) conformation
of the EPLP peptide. HLA-B^*3501 1
and 2
helices, gray ribbon. The 2
helix is removed from b for clarity. (d) Peptide interactions
with the ELS4 TCR.
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