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Figure 4.
Figure 4: AID HIGM-2 mutations.
Figure 4 : AID
HIGM-2 mutations. Unfortunately we are unable to provide
accessible alternative text for this. If you require
assistance to access this image, or to obtain a text
description, please contact npg@nature.com-
a, Alignment of mutated residues of AID from HIGM-2 patients
with the corresponding residues in APO2, showing high sequence
conservation. b, Mapping the residues in AID HIGM-2 mutations
(R112, L113, N168) to the tetramer interface as modelled from
the APO2 structure. c, Mapping the AID HIGM-2 mutations, S83 and
S85, near the active site. d, Mapping the AID mutations, K16,
Y114/F115 and C116 (in green), to the exposed surface of an
outer monomer. The HIGM-2 AID residues (R112, L113, N168, in
yellow), which are at the tetramer interface (b), are also
located on this exposed surface. e, Mapping of AID HIGM-2
mutations, W80, L106, M139 and F151, to the interior core
structure.
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