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Figure 4.
Figure 4 Structural details of T-ag interaction with DNA bases
in the PEN-2 and PEN-4 structures. (A) Sequence-specific
interaction of Arg 154 with G1 (the first G in the GAGGC
pentamer) in the PEN-4 structure. A representative electron
density map (shown in blue) is superimposed on the model. (B)
Nonspecific interaction of Arg 154 with A1 (A in position of G1)
in the PEN-2 structure. A representative electron density is
superimposed on Arg 154. (C) Sequence-specific interaction of
Ser 152 with A2. (D) Nonspecific interaction of Ser 152 with the
T2 in the PEN-2 structure. Sequence-specific interactions, which
involve (E) the G3 and Asn 153, (F) the G4 and Asn 153, and (G)
the G (complementary to C5) with Arg 204. The protein and DNA
are shown as stick models and colored by atom type; yellow for
carbon, blue for nitrogen, red for oxygen, and purple for
phosphorus. A representative electron density as captured from
2F[o]-F[c] map is shown with contours drawn at the 1.25  level.
Hydrogen bonds are indicated with red dashed lines, and the
length of the bonds is indicated in Å.
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