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Figure 4.
Figure 4. Electrostatic surface potentials of (A) TSP TSR2, (B)
F-spondin TSR1, and (C) F-spondin TSR4. Each domain is shown
from two sides, which are rotated by 180° around a vertical
axis relative to each other. For the F-spondin TSR domains, the
structures with the lowest total energy are shown. Charged
residues are labeled. Red labels identify residues that are
conserved in the sequence alignment and have similar positions
on the surfaces of all three domains. The charged side-chains
D496, E497, and D498 in F-spondin TSR1 and D625, K632, K642,
E646, D649, and D653 in F-spondin TSR4 have larger than 2
Å side-chain RMSDs.
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