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Figure 4.
Fig. 4. The SARS-CoV PLpro and USP14 active sites. (A)
SARS-CoV PLpro catalytic triad residues, C112, H273, and D287,
and other important active-site residues. Distances between
residues are indicated in angstroms. The hydrogen bond between
D109 and W97 is indicated by an arrow. (B) Comparison of USP14
and SARS-CoV PLpro BL1 and BL2 loop regions. Corresponding
regions of unbound USP14 (red), Ubal-complexed USP14 (yellow),
and PLpro (blue) are shown superimposed. The BL1 and BL2 loop
regions are indicated. The BL1 loop region of PLpro is colored
in green. The catalytic triad residues are shown by a
ball-and-stick representation.
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