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Figure 4.
Figure 4. Shape Reconstructions
(A) Kinase domain. The
backbone of the crystal structure of the c-Abl kinase domain
(blue; PDB code 1OPJ) is superimposed onto the shape
reconstruction (shown as green mesh).
(B) Abl^N-cap.
Superimposed is the crystal structure of Abl^N-cap shown as a
green backbone onto the shape reconstruction (gray mesh).
(C) Abl^activated. The kinase domain and SH2 and SH3 domains are
colored red, green, and blue, respectively. Indicated on the
right view is the part of the model that may correspond to the
crystal structure of disassembled c-Abl from the original
crystallographic analysis of c-Abl 1b. The SH3 domain was placed
by visual inspection, ensuring that its C terminus was in close
proximity to the N terminus of the SH2 domain.
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