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Figure 4.
FIGURE 4. Displacement of the crystal structure between the
wild type (Protein Data Bank code 1DYI; cyan) and ANLYF
(magenta). The r.m.s.d. calculated by using the backbone atoms
of the adenosine binding subdomain, the loop subdomain, and
folate of the two crystal structures was minimized in A-C,
respectively. The regions used for calculating r.m.s.d. are
colored explicitly in gray. D and E show representative residues
located in the vicinity of the axis of the hinge motion, in
which Met-42 (Tyr-42) (green) and Met-92 (Phe-92) (orange) are
also included for the wild type and ANLYF, respectively. Folates
colored blue and red are bound with the wild type and ANLYF,
respectively. All the panels were drawn using a program MOLMOL
(66).
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