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Figure 4.
Fig. 4. Molecular contacts at the toxin–receptor
interface. (A and B) Details of molecular contacts between
Ac-AChBP and  -conotoxin PnIA(A10L
D14K) (A) and -conotoxin ImI (B). The
conotoxin is shown in red, the principal binding side in yellow,
and the complementary binding side in blue. Disulfide bridges
are green. Dashed lines indicate H-bonds or salt bridges. (C)
Sequence alignment of Ac-AChBP, Ls-AChBP, and [7],
[9], [3],
 [4]
nAChRs. Sequence numbering at the top is for Ac-AChBP and at the
bottom is for [7] nAChR. Residues of
the principal binding side that interact with -conotoxin ImI are
shown in yellow; residues of the complementary binding side are
in blue. Contacts that are present in the complex with ImI, but
not in the complex with PnIA(A10L D14K), are labeled with  below
the alignment.
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