Figure 4 - full size

 

Figure 4.
Fig. 4. A potential mechanism for proton-dependent drug translocation by EmrE. For clarity, only the three putative gating helices (A1, A2, and B1) and two membrane-embedded Glu-14 side chains are shown explicitly. Drug substrates and protons are represented by the yellow sphere and red balls, respectively.

The above figure is reprinted by permission from the AAAs: Science (2005, 310, 1950-1953) copyright 2005.