Figure 4.
Figure 4: Pre-attack conformation of the substrates. The
hydroxyl group representing the -amino
group of the A-site substrate, CChPmn (purple) is in position to
attack the ester group of the P-site substrate CCApcb (green).
It is within hydrogen-bonding distance of N3 of A2486(2451) and
the 2' hydroxyl group of the P-site substrate. In this ground
state, the reactive groups are 3.7 Å apart.
The above figure is reprinted
by permission from Macmillan Publishers Ltd:
Nature
(2005,
438,
520-524)
copyright 2005.
-amino
group of the A-site substrate, CChPmn (purple) is in position to
attack the ester group of the P-site substrate CCApcb (green).
It is within hydrogen-bonding distance of N3 of A2486(2451) and
the 2' hydroxyl group of the P-site substrate. In this ground
state, the reactive groups are 3.7 Å apart.